Rare Alzheimer’s Mutation Reveals Unexpected Disease Mechanism
Summary: The S198P mutation accelerates folding of the amyloid precursor protein (APP), enabling mature APP to produce amyloid-beta (Aβ) peptides more rapidly than the non-mutant form. This discovery reveals a previously unrecognized mechanism by which a rare genetic change can contribute to Alzheimer’s disease. Source: University of Chicago Medical Center Researchers at the University of … Read more