Researchers Reverse Key Schizophrenia Symptom in Adult Mice
Summary: Neurons in mice lacking normal SETD1A function show shorter, stunted branches. Turning off the gene LSD1 reverses the harmful effects of SETD1A deficiency, restoring axon growth and improving working memory. Pharmacological inhibition of LSD1 corrected both the cellular defects and the behavioral memory deficits seen in this schizophrenia model. Source: Zuckerman Institute at Columbia … Read more