Summary: Researchers have identified a cellular pathway involving the protein Rab35 that restricts glioblastoma growth and invasiveness. The study suggests restoring Rab35 activity could offer a new therapeutic approach for this aggressive brain cancer. Source: Rockefeller University Press Rab35 and Arf5 pathway limits glioblastoma growth, McGill study shows Scientists at McGill University have uncovered a … Read more

Haven’t we all felt it? That nagging sense that we’ve tricked others about our abilities and don’t truly belong. Often it’s less about what we claim and more about what we fail to accept about our own competence. Imposter syndrome involves persistent self-doubt and a fear of being exposed as a fraud. It can undermine … Read more

Summary: New research led by UCL indicates that a young child’s tendency to eat more or less in response to stress or negative emotions is shaped largely by the home environment rather than by genetic factors. Parental behaviour and family mealtime context appear to be important influences. Source: UCL. Home environment, not genes, is the … Read more

Summary: Antidepressant medication for major depressive disorder appears to reduce the emotional response evoked by seeing others in pain. New findings indicate that antidepressant treatment—rather than the depressive episode itself—can diminish empathy for perceived pain. Source: University of Vienna Overview Depression frequently disrupts social functioning, and impaired empathy has long been considered part of the … Read more

We all begin life in a family—whether that family consists of blood relatives, adoptive parents, a strong neighborhood network, or foster caregivers. The family we are born into shapes many aspects of our lives, from our earliest memories to the person we grow into. Families teach us language, habits, customs, rituals, and how to see … Read more

Summary: Researchers have developed a small-molecule drug that shows promise as a new approach to treating multiple sclerosis (MS). Unlike current therapies that primarily target the immune system, this experimental compound acts on the brain’s glutamate signaling pathways and, in preclinical studies, both reduced MS-like symptoms and promoted repair of damaged myelin. The treatment demonstrated … Read more

Summary: Researchers at Scripps Research have identified a promising new approach to treating opioid use disorder (OUD) by using a compound that targets metabotropic glutamate 2 (mGlu2) receptors. The investigational drug, ADX106772, reduced oxycodone self-administration and cue-induced drug-seeking in an animal model without impairing natural reward behaviors, pointing to a potential new therapy for prescription … Read more

The Connor-Davidson Resilience Scale was developed by two researchers, Kathryn M. Connor and Jonathan R.T. Davidson. Kathryn Connor is a psychiatrist and researcher at Duke University Medical Center in Durham, North Carolina. Her work focuses on stress, anxiety disorders, social anxiety, psychopharmacology, and resilience. Jonathan Davidson is Professor Emeritus of Psychiatry and Behavioral Science at … Read more

Summary: VPS35 is a newly identified key regulator of tau metabolism and plays a critical role in the pathology of neurodegenerative diseases. Source: Temple University Health System Overview: A protein called VPS35 acts like a cellular sorting machine, identifying and directing defective proteins to degradation pathways in neurons. New research from the Lewis Katz School … Read more

Summary: A new study asks whether a genetic variant tied to neurodegeneration in modern settings might provide benefits in different, infection-rich environments. Source: Arizona State University. Study finds cognitive decline may depend on the interaction between genes and environment — even parasites. We often talk about being in the right place at the wrong time. … Read more