Summary: A recent review examines the complex, changeable relationship between working memory—the brain’s short-term storage—and our conscious experience. Drawing on decades of classic change-detection experiments and contemporary neurocognitive models, the author questions strict “all-or-nothing” accounts of memory and proposes a more nuanced “Spectrum Model” of working memory. According to this view, consciousness is not a … Read more

Summary: Researchers show that the effectiveness of anti-CTLA-4 immunotherapy against brain tumors depends not only on local T cells but critically on a robust B-cell and antibody response that is initiated far from the tumor, within the deep cervical lymph nodes of the neck. By revealing that anti-CTLA-4 stimulates the production of tumor-targeting Immunoglobulin G … Read more

Summary: Researchers developed a real-time brain-computer interface (BCI) that functions as a closed-loop training tool for the subconscious mind. By decoding a specific electroencephalogram (EEG) signature known as the Error Positivity (Pe) wave, the system trained participants to increase conscious awareness of very small visuo-motor errors. The result was rapid, accelerated perceptual learning that surpassed … Read more

Summary: Analyzing data from the long-running Atherosclerosis Risk in Communities (ARIC) study, researchers found that adults who reported watching television “very often” in midlife later showed notable tissue loss in brain regions tied to memory, executive function and vision. In contrast, prolonged sitting during cognitively demanding work was associated with healthier brain structure, highlighting that … Read more

Summary: Researchers developed a precise patterned stimulation protocol called REPOPS (Repeated Electroconvulsive-like Patterned Optical/Electrical Stimulation) in mice to reproduce the neural activation signature of electroconvulsive therapy (ECT). The results reveal a dramatic cellular transformation: intensive ECT-like stimulation pushes fully mature, non-dividing adult neurons into an active process of cellular dematuration, a reversible shift toward an … Read more

Summary: Researchers have built an AI-driven speech neuroprosthesis that decodes high-density intracortical signals into fluent, high-quality synthetic speech. The system uses a two-stage deep learning pipeline—a phonetic decoding layer followed by a large language model-based linguistic processor—to reach better than 99% word accuracy while operating with about 30 milliseconds of processing latency. Tested with a … Read more

Summary: Researchers have uncovered an unexpected phase of circuit remodeling confined to a key memory-storage region in the brain. Using precise mouse models, the team revealed that perineuronal nets (PNNs)—protective extracellular lattices that enwrap neurons to stabilize long-term memory traces—undergo a transient breakdown during late adolescence. This targeted PNN degradation makes memories formed earlier in … Read more

Summary: An international research team has identified a major genetic cause of primary hyperhidrosis. By sequencing and analysing the DNA of more than 180 patients, researchers traced a consistent cause to mutations in the Nav1.8 (SCN10A) voltage-gated sodium channel. In affected individuals this ion channel is pathologically open, producing a continuous electrical leak that chronically … Read more

Summary: Using an in-house high-contrast tau PET tracer, researchers mapped tau deposits in 37 people with progressive supranuclear palsy (PSP) and combined those maps with normative functional connectivity data from 100 healthy brains. This integrated approach revealed a shared, remote circuit—the “PSP-tau network”—through which localized subcortical tau lesions appear to disrupt distant cortical regions that … Read more

Summary: A large U.S. study of more than 8,900 mother–infant pairs found no evidence that acetaminophen (Tylenol) taken during pregnancy increases the risk of preterm birth or alters average birth weight. After rigorous statistical adjustments, the research team at the UNC Gillings School of Global Public Health reports no association with preterm birth, birth weight, … Read more