Using three-dimensional “mini-brains” grown from patient-derived induced pluripotent stem cells (iPSCs), researchers at the University of California, San Diego School of Medicine report identifying a drug candidate that can reverse cellular dysfunction in MECP2 duplication syndrome by suppressing a key genetic abnormality. The study appears in the September 8 online issue of Molecular Psychiatry. MECP2 … Read more

Summary: Researchers have created a new, high-resolution 3D model of the CA1 area of the human hippocampus at single-cell resolution. Source: Human Brain Project Researchers at the Institute of Biophysics of the Italian National Research Council (CNR-IBF) and the University of Modena e Reggio Emilia (UNIMORE), working with the Human Brain Project, have produced a … Read more

Summary: A new study offers a possible explanation for why men infected with the novel coronavirus often experience more severe illness and face a higher risk of death than women. Investigators focused on ACE2 receptors—the entry point the virus uses to infect human cells—and report that the testes, along with the lungs and kidneys, show … Read more

Summary: Collaborative efforts have produced a detailed atlas of the mouse brain, revealing how diverse cell types are organized, connect, and are regulated. These findings lay groundwork for future studies and therapies targeting brain disorders. Source: Salk Institute Mapping the brain requires untangling billions of cells and their connections. A multi-institutional collaboration led in part … Read more

Some brain tumors are notoriously difficult to treat. Whether removed surgically, targeted with radiation, or treated with chemotherapy, they often return. Many recurrent brain tumors owe their resilience to a subpopulation of cancer stem cells that survive therapy and regenerate new tumor tissue. These cells are more treatment-resistant and are capable of repopulating tumors after … Read more

Summary: A new study finds that viewing average and plus-size fashion models is linked with improved psychological wellbeing for women compared with viewing thin models. Source: Florida State University. A Florida State University study shows that women pay more attention to—and remember more about—average and plus-size fashion models in the media, and that exposure to … Read more

Summary: Light-sensitive cells in the fetal retina form an interconnected network, increasing retinal sensitivity to light during development more than previously recognized. Source: UC Berkeley By the second trimester, well before a newborn can form visual images, the developing eye can detect light. Researchers once believed these early light-sensitive retinal cells acted as simple on-off … Read more

A five‑week course of the synthetic hormone oxytocin, given as a nasal spray, produced significant improvements in social, emotional and behavioral difficulties in young children with autism, according to research from the University of Sydney published in Molecular Psychiatry. Led by investigators at the University’s Brain and Mind Centre, this trial provides the first clinical … Read more

Summary: New research examines how an allostatic closed‑loop neurotechnology affects resting‑state brain connectivity and lateralization in people with military‑related traumatic stress. Source: Cereset HIRREM, the legacy closed‑loop neurotechnology developed by Cereset (a Brain State company), was used in a Wake Forest School of Medicine study to evaluate changes in symptoms and brain connectivity in military … Read more

Summary: In healthy older adults, a controlled course of hyperbaric oxygen therapy was associated with cellular signs of biological rejuvenation. Source: AFTAU A Tel Aviv University (TAU) study in collaboration with the Shamir Medical Center reports that a specific regimen of hyperbaric oxygen therapy (HBOT) produced measurable cellular changes consistent with reversing aspects of biological … Read more