Summary: Researchers have shown that axon formation is an autonomous, internally driven process. Young neurons use an internal protein complex to systematically loosen their own cytoskeletal scaffold from the inside out, establishing the early wiring of the nervous system through an intrinsic genetic program. Key Facts The Intrinsic Control Shift: Instead of relying primarily on … Read more

Summary: New research using simultaneous EEG and fMRI demonstrates that the human brain does not run a single unified process. Instead, the connectome coordinates multiple independent, asynchronous streams of information processing that run in parallel. This finding alters how researchers interpret fMRI and EEG signals and opens new possibilities for clinical neuro-diagnostics and studies of … Read more

Summary: An international team of paleontologists has identified the earliest known example of population-level “handedness” in the animal kingdom. By analyzing more than 100 exceptionally preserved fossils of the Ediacaran organism Spriggina floundersi, researchers found a consistent, population-wide bias for bending to the right in life. These results indicate that lateralized behavior—and by implication, asymmetry … Read more

Summary: Researchers have shown that BA-101, an experimental compound, can strip away a key defensive mechanism used by glioblastoma. By selectively inhibiting the neuronal nitric oxide synthase (nNOS) enzyme that drives excessive nitric oxide production, BA-101 dismantles the tumor’s nitrosative stress shield. In preclinical models this restores sensitivity to temozolomide, slows tumor growth, and promotes … Read more

Summary: Researchers have shown that breakdown of the myelin sheath—the insulating layer that surrounds nerve fibers—destabilizes brain circuits and produces distinctive sleep-only electrical abnormalities. Continuous multi-night electroencephalogram (EEG) recordings in animal models revealed epilepsy-like spikes that appear only during sleep and a marked slowing of REM sleep oscillations. These sleep-linked electrical signatures closely track myelin … Read more

Summary: A multi-institutional team reviewed medical and mortality records spanning six decades and found that former National Football League (NFL) players have markedly higher rates of death from neurodegenerative diseases than the general population. Although NFL veterans show lower overall mortality, they are about four times more likely to die from neurodegenerative conditions—including dementia and … Read more

Summary: Dartmouth researchers combined eye-tracking in virtual reality headsets with machine learning and large language models (LLMs) to show that our gaze is guided by deep, personal “conceptual priorities.” Rather than only following bright or prominent objects, people tend to seek out items that carry abstract, meaningful themes for them. These thematic viewing patterns are … Read more

Summary: The Technology for Aging Health – Digital Approaches (TAH-DA) study follows adults across five decades to collect continuous, real-world biometric data. By providing participants across North America with commercial wearable devices and tablets, this cross-sector effort aims to create robust, deployable algorithms that can detect early signs of cognitive decline through passive, continuous monitoring … Read more

Summary: The Alzheimer’s Tau Platform (ATP) trial is the first large-scale study specifically designed to evaluate combination therapies that target both amyloid plaques and tau tangles at once. Uniquely, ATP screens and treats people who are asymptomatic but show early biological indicators of Alzheimer’s on advanced imaging, with the aim of interrupting the disease process … Read more

Summary: An international team of researchers from more than 20 institutions synthesized decades of clinical and experimental work to explain how many modern, human-made environments overload our visual systems. Combining mathematical analysis of natural scene statistics with neurocomputational models, the review identifies how common urban patterns—repeating geometry, high contrast, flicker, and clutter—drive excessive neural activity … Read more