Summary: Researchers have found that the three-dimensional folding of the genome is substantially altered in specific brain cells of people with Alzheimer’s disease, revealing a new layer of molecular pathology linked to disrupted gene regulation and tissue organization in the prefrontal cortex. The study combines single-cell GAGE-seq multiomics, spatial tissue mapping, and a transformer-based deep … Read more

Summary: A new single-cell multiomic study finds that the human brain undergoes coordinated shifts in gene regulation and three-dimensional genome architecture beginning in midlife. By profiling individual cells across the adult lifespan in the hippocampus—a region essential for learning and memory—researchers mapped structural genome breakdown and system-level remodeling that help explain why aging is the … Read more

Summary: New UCLA-led research shows that blocking an overactive mTOR signaling pathway quickly calms hyperexcitable neurons, restores disordered functional brain networks, and reduces repetitive and sensory-overresponsive behaviors in adult mice exposed to prenatal inflammation. Effects appeared within roughly two hours, a timeframe too brief to reflect structural repair, indicating that adult brains retain substantial functional … Read more

Summary: Researchers examined how rapid time zone changes disrupt the bidirectional communication of the gut-brain-immune axis. When sleep patterns, light exposure, and meal timing shift abruptly, coordination between the brain and peripheral clocks in the gut breaks down, impairing intestinal barrier function and altering the microbiome. This temporal misalignment reduces the production of beneficial short-chain … Read more

Summary: A new study identifies a phenomenon called “informational tuning”: although the total raw information transfer is unexpectedly greater under anesthesia, the awake brain channels information with high directional precision along the paths of traveling waves. This spatial sharpening supports reliable cortical communication in wakefulness, while anesthesia disrupts the tuning and produces unstructured, noisy signal … Read more

Summary: Researchers report that fruit flies (Drosophila melanogaster) find odor sources not by simple reflexes but by using a directional memory system. This internal vector-based strategy lets them track the edge of an odor plume and reorient back to the scent even when the plume shifts or the wind changes. Using a virtual-reality treadmill combined … Read more

Summary: Researchers have introduced the world’s first chip engineered to operate at the millisecond timescale of the human brain. Built on a standard 40-nanometer manufacturing process, this sub-10-millisecond neural dynamical system uses phase-change memristors to perform core mathematical operations directly inside memory. The complete design fits within 0.28 square millimeters and delivers dramatic performance and … Read more

Summary: A comprehensive analysis of immune cells from human blood, cerebrospinal fluid (CSF), and intestinal mucosal tissue in control individuals and multiple sclerosis (MS) patients treated with B-cell depletion reveals a previously unrecognized mechanism. Rather than working solely by removing disease-driving B cells, anti-B-cell therapy appears to alter systemic regulatory signals and actively mobilize protective, … Read more

Summary: Using high-speed videography and automated pose estimation, researchers found that individual hummingbird hawkmoths consistently place the tip of their proboscis to one side of their body midline while inspecting flowers. This motor bias aligns with a dominant eye, forming a stable eye–proboscis–target control axis that reduces computational demands on the moth’s small brain. Key … Read more

Summary: In a 6-hydroxydopamine (6-OHDA) mouse model of Parkinson’s disease, researchers gave daily doses of L‑DOPA/carbidopa from day 13 to day 30 after lesion, either alone or combined with freeze-dried bee venom. Behavioral testing showed that the combination produced markedly better outcomes than standard therapy alone. Mice treated with L‑DOPA/carbidopa plus bee venom preserved nearly … Read more