Summary: A retrospective study indicates that people treated with lithium, a medication commonly used for bipolar disorder, had a lower incidence of dementia compared with those who did not receive lithium. Source: University of Cambridge Researchers at the University of Cambridge report an association suggesting lithium use may reduce the risk of developing dementia, a … Read more

Summary: Brain performance can improve in some older adults when they perform a challenging cognitive task while walking. Source: University of Rochester Scientists seeking clues to prolonged cognitive vitality have long searched for so-called “super-agers”—people whose brains maintain or even improve function despite aging. New research from the Del Monte Institute for Neuroscience at the … Read more

Protein deposits linked to dementia alter brain activity during sleep Sleep disturbances are a common symptom in people with Alzheimer’s disease, often appearing before noticeable memory loss. Sleep is also crucial for consolidating memories: during deep non-REM sleep the brain generates slow oscillations, or slow waves, that help transfer newly learned information into long-term storage. … Read more

Summary: A UCL-led study indicates that amyloid beta deposits in the brain’s blood vessels may, in some cases, have been transmitted decades earlier by contaminated neurosurgical instruments. Source: UCL. Amyloid beta protein deposits in brain blood vessels may have been transmitted via contaminated neurosurgical instruments, according to a new UCL-led analysis. Published in Acta Neuropathologica, … Read more

Summary: The ion channel TRPC5 functions as a molecular cold sensor in teeth. Researchers identify TRPC5 as a potential target for reducing toothache pain and cold sensitivity. Source: HHMI For many people with tooth decay, even a sip of a cold drink can cause sharp, stabbing pain. “It’s a very specific kind of pain,” says … Read more

Summary: A large randomized trial found that weekly injections of the weight‑loss medication Wegovy (semaglutide 2.4 mg) were associated with significantly lower mortality: COVID‑19–related deaths were reduced by about one‑third and overall deaths fell by roughly 19% compared with placebo. The multicenter study followed more than 17,000 adults with established cardiovascular disease and overweight or … Read more

Summary: The COVID-19 pandemic led to a measurable rise in reported paranoia, with the strongest effects seen in U.S. states that imposed mask mandates but experienced low compliance. The Yale team found that higher paranoia was linked to greater acceptance of conspiracy theories, including anti-vaccine claims and QAnon narratives. Source: Yale New research from Yale … Read more

Summary: Researchers at Boston Children’s Hospital and collaborators are advancing vaccine strategies against coronavirus infections. While a broadly available COVID-19 vaccine may still be more than a year away, teams are prioritizing approaches that protect the most vulnerable—particularly older adults—and preparing platforms to respond to future coronavirus outbreaks. Source: Harvard As global cases of the … Read more

Summary: New research shows that excitatory neurons are particularly susceptible to the buildup of abnormal tau protein, a hallmark linked to Alzheimer’s disease. Source: Ohio State University Improved detection, prevention and treatment strategies for Alzheimer’s disease require a detailed understanding of changes at the cellular level. A recent study provides new insight into why a … Read more

Summary: Deleting the microglial gene CX3CR1 worsens disease progression and increases plaque accumulation in mouse models of Alzheimer’s disease. Loss of this gene also reduces microglial migration toward amyloid plaques, impairing their clearance. Source: Indiana University Researchers at Indiana University School of Medicine examined how loss of a microglial gene shapes Alzheimer’s disease progression. Published … Read more