Summary: Blood levels of two protein biomarkers—GFAP and UCH-L1—measured within 24 hours of a traumatic brain injury (TBI) can help predict which patients are at highest risk of death or severe disability six months later. Source: UCSF Blood tests taken within 24 hours of a traumatic brain injury (TBI) can indicate which patients are likely … Read more

Summary: Findings could lead to new treatments for asthma. Source: RUB. Researchers identified two types of olfactory receptors in human bronchial smooth muscle cells. Activating these receptors with specific odorants causes the bronchi to either dilate or contract, revealing a potential new approach for asthma and other airway disease therapies. A research team led by … Read more

Summary: A new study finds that older adults who begin dialysis for advanced kidney disease face a substantially higher risk of dementia, including Alzheimer’s disease. Source: Johns Hopkins University. Older adults with end-stage kidney disease who start dialysis face a markedly increased risk of being diagnosed with dementia, including Alzheimer’s disease, according to research led … Read more

Summary: Texas A&M researchers report that fentanyl increases activity of direct-pathway medium spiny neurons (dMSNs) in the striatum. During early withdrawal, these dMSNs send stronger inhibitory signals to downstream dopamine-producing neurons, creating a hypodopaminergic state that contributes to the negative emotions and anxiety seen in withdrawal. Suppressing dMSN activity reduced withdrawal symptoms and anxiety-like behaviors … Read more

When they’re not the stars of animated films, penguins play a vital role in studies of evolution. Penguins are unique among modern birds because, although they cannot fly in air, they ‘fly’ through water. Their wing-propelled swimming depends on a suite of anatomical adaptations—some of which are found in unexpected places, including the brain. Recent … Read more

Summary: Researchers have demonstrated that non-invasive transcranial ultrasound stimulation (TUS) can alter human reward learning by targeting the nucleus accumbens, a deep brain region central to motivation. After brief, focused stimulation, participants learned more quickly from positive feedback and showed a greater tendency to repeat choices that had previously been rewarded. These changes resemble important … Read more

Summary: Transcranial pulsed stimulation (TPS) and other focused ultrasound techniques can non-invasively target and modulate deep brain regions, opening new treatment possibilities for a wide range of neurological and psychiatric disorders. Source: University of Vienna Targeted ultrasound is emerging as more than an imaging tool: focused acoustic pulses can now be used to treat brain … Read more

Every time you speak a word, take a step, or read a sentence, networks of neurons relay information across the brain. Researchers now have a powerful new way to watch those messages in real time by seeing each neuron light up when it fires. When a neuron receives input from another cell, a brief cascade … Read more

Summary: New research reveals that the cerebellum contributes not only to movement control but also to cognitive processes such as short-term memory and motor planning. Source: Baylor College of Medicine. Background For decades neuroscientists have assigned different brain regions to specific functions: the cerebellum was primarily linked to motor control and coordination, while the frontal … Read more

More than a century of research has shown that sleep supports the retention of memories for facts and events. New analysis suggests that deep, slow-wave sleep—the stage associated with consolidating fragile, newly formed memories into stable, long-lasting ones—may also reinforce the immune system’s memory of previously encountered pathogens. In an Opinion article published September 29 … Read more