Summary: A new study overturns the long-standing “inside-out” model of cortical development by showing that radial glial progenitor cells branch early into parallel lineages. Using Mosaic Analysis with Double Markers (MADM) single-cell lineage tracing, researchers demonstrated that radial glial progenitors split at the onset of neurogenesis into distinct developmental trajectories that produce different populations of … Read more

Summary: Researchers at the Japan Advanced Institute of Science and Technology (JAIST) have introduced EMF-dVAE (Efficient Multimodal Fusion with a discrete Variational Autoencoder), a brain-inspired AI framework that selectively filters redundant visual frames in video streams. By concentrating on the most informative moments—guided by audio cues—the model reduces computation while improving prediction accuracy. Key Facts … Read more

Summary: A new study examines how the phosphoserine phosphatase (PSPH) gene has changed in function over human history. PSPH encodes the enzyme phosphoserine phosphatase, which catalyzes the final step in L-serine biosynthesis. L-serine is an amino acid essential for central nervous system development and maintenance; insufficient synthesis caused by pathogenic PSPH variants results in severe … Read more

Summary: Researchers evaluated dronabinol, a plant-derived Δ9‑tetrahydrocannabinol (THC) formulation, for treating trauma-related nightmares in people with post-traumatic stress disorder (PTSD). The randomized, double-blind, placebo-controlled trial found a statistically significant reduction in nightmare burden for patients receiving dronabinol versus placebo. By week ten, more than one third of patients on dronabinol reported complete resolution of nightmares, … Read more

Summary: A nationwide Swedish study of more than 40,000 patients diagnosed with inflammatory bowel disease (IBD) between 2007 and 2023 found a substantially increased risk of psychiatric disorders. By comparing IBD patients with nearly 180,000 matched population controls and some 26,000 IBD-free full siblings, the researchers showed that elevated mental health risk begins years before … Read more

Summary: Researchers achieved the first direct molecular mapping of how deep brain stimulation (DBS) affects human cortical tissue by applying DBS-like electrical patterns to living human temporal cortex slices maintained ex vivo. Using donated neurosurgical brain tissue kept alive in the laboratory for several days, the team applied stimulation patterns similar to clinical DBS and … Read more

Summary: Researchers have reported the successful completion of a Phase 1b clinical trial of a novel immunotherapy for Alzheimer’s disease. The investigational agent, IBC-Ab002, is a humanized anti-PD-L1 monoclonal antibody designed to rejuvenate systemic immune responses rather than directly remove neurotoxic amyloid beta plaques in the brain. Key Facts Established safety profile: The Phase 1b … Read more

Summary: A new PET imaging study shows that hallucinations and delusions that first appear after age 40 are often linked to underlying neurodegenerative changes. Using molecular positron emission tomography (PET), researchers found tau protein accumulation in roughly 65% of late-onset psychosis patients versus 15% of age-matched healthy controls, and amyloid beta positivity in 35% of … Read more

Summary: A large Penn State analysis of survey responses from nearly 200,000 Pennsylvania adolescents examined which social and community factors protect young people from suicidal thoughts and behaviors. The study finds that strong bonds with family, meaningful engagement in school, and visible community recognition consistently lower suicide risk. These relational protections work both directly and … Read more

Summary: Researchers have created a highly reproducible three-dimensional human brain tissue model that replicates key neurodegenerative processes seen in Alzheimer’s disease. Developed over nine years from human induced pluripotent stem cells, these self-organizing tissue spheroids combine functional neurons, supportive astrocytes, and immune-competent microglia into compact micro-architectures roughly the size of half a pinhead. The engineered … Read more