Summary: Researchers at Carnegie Mellon University created the first sensory-guided joint learning framework for noninvasive brain-computer interfaces (BCIs). By establishing a two-way, unified loop that aligns human trial-and-error learning with adaptive machine algorithms, the team achieved high control precision with entirely untrained users. This approach overcomes long-standing calibration limits and points toward scalable, everyday assistive … Read more

Summary: A large international study confirms that the blood biomarker phosphorylated tau 217 (p-tau217) provides long-term prognostic information about the risk of developing cognitive impairment. Cognitively normal individuals with very high baseline p-tau217 levels faced an absolute 38% risk of cognitive impairment within five years and a 78% risk within ten years. These risk estimates … Read more

Summary: A large-scale analysis of International Brain Laboratory recordings spanning 43 mouse cortical regions finds that multi-purpose “generalist” neurons are the dominant organizational principle in mammalian cortex. While primary sensory regions retain specialist cells, higher-order cortical areas predominantly use high-dimensional population codes in which individual neurons jointly represent many task-relevant variables without simple, redundant tuning. … Read more

Summary: A collaborative research effort has introduced Centered Daydreaming, a refined learning rule for Hopfield networks that combines simultaneous daytime learning with continual pruning. By shifting the network’s focus from absolute pixel values to deviations from a running average, the team pushed storage capacity to its theoretical limit—one full memory per neuron (100%)—even for highly … Read more

Summary: Researchers at North Carolina State University have developed BINND (Binding and Interaction Neural Network for DNA), a novel deep learning model trained on an unprecedented dataset of 144 million sequence pairs. BINND predicts complex DNA–DNA binding affinity and interaction patterns with high accuracy, outperforming prior methods and providing a practical tool to advance DNA … Read more

Summary: Researchers examined how sleep chronotypes, meal timing, body composition and blood biomarkers interact in adult women. The study found that although “night owls” and “early birds” consume similar total daily calories, night owls concentrate much of their intake late at night. This misalignment with the body’s natural fasting period links to higher body fat, … Read more

Summary: In a large study of nearly 6,000 children, researchers found that raw amygdala activation while viewing emotional faces reliably forecasted an adolescent’s social involvement two years later. Importantly, this neural signature predicted opposite social outcomes for boys and girls. Key Facts Amygdala as a unique predictor: Among the core regions of the social brain … Read more

Summary: A randomized, placebo-controlled clinical trial shows a specially formulated oral THC/CBD medical oil produced rapid, substantial reductions in end-of-life agitation among people with late-stage dementia. The Phase 2 LiBBY trial followed 120 hospice-eligible participants and found a 6.27-point greater decrease in Cohen‑Mansfield Agitation Inventory (CMAI) scores in the active treatment arm versus placebo within … Read more

Summary: A collaborative study combines detailed rodent circuit mapping with ultra-high-field 7T human fMRI to reveal how upstream brain regions regulate the periaqueductal gray (PAG), a core midbrain center for defensive responses. By identifying the human networks that inhibit or modulate the PAG, the team aims to develop real-time fMRI neurofeedback therapies that help people … Read more

Summary: A new study uses Koopman operator learning to show that some complex, chaotic systems have fundamental limits to predictability that cannot be overcome simply by adding more training data. By constructing adversarial dynamical systems that expose where data-driven models must fail, the research team revealed mathematical causes of long-horizon errors — including the hallucinations … Read more